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NGS Characterized Biospecimens

Thousands of specimens characterized via NGS across over 20 oncology indications
Precision has created an extensive collection of oncology biospecimens characterized via NGS. These biospecimen sets can include tumor, normal, and adjacent tissues, DNA/RNA, H&E images, and detailed characterization data.

Precision for Medicine’s NGS-characterized biospecimens library

Library details

Library details

13K+ Biospecimens

23 Oncology indications

Sequenced via :

  • Oncomine precision assay

  • truSighttm oncology 500 assay

Biospecimen types

Biospecimen types

FFPE blocks: Tumor, normal, and adjacent tissue

H&E images for every biospecimen

Isolated DNA/RNA for most samples

Precision Lab e-Portal

Available data

  • Characterization Data

  • Surgical Pathology Report

  • Histologic Subtype

  • Grade/Stage

  • Demographics

Total specimen counts

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Details of Precision’s library of two NGS-characterized biospecimen indications: variant data for lung cancer and colorectal cancer biospecimens

Lung Cancer Biospecimens by Variant

 

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Colorectal Cancer Biospecimens by Variant

 

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Deeper dive Into lung cancer characterization data

Lung Cancer Biospecimens by Cancer Subtype

 

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Colorectal Cancer Biospecimens by Variant

 

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NGS-characterized biospecimens and data available:

 

1. FFPE Tissue Slides

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2. Characterization Data

Below is a table showing examples of some of the data available. Additional (not shown) data include: Surgical procedure, Stage, Demographics, % Tumor, % Necrosis, NGS assay

NG characterized specimens data example

3. H&E Images

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4. DNA/RNA

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Additional methods available to analyze and characterize biospecimens

In addition to a selection of high-quality characterized biospecimens, Precision provides specialty lab services to assess these biospecimens using several technologies, including:

  • IHC and mIF

    • Leica BOND
    • Dako Omnis, Dako Link 48, Artisan
    • Ventana BenchMark
    • Akoya Phenolmager™ HT
    • Pathology Services

  • Digital pathology and slide scanning

    • Proscia Concentriq®
    • Aperio GT 450
    • Aperio AT2
    • 3DHISTECH

  • NGS and Genomics

    • NGS: multiple platforms
    • NanoString
    • ddPCR, qPCR
    • 10x genomics

Learn more about the uses of characterized biospecimens

Whitepaper

Characterized Biospecimens: A Guide for Leveraging Deeply Characterized Biospecimens

Download Whitepaper
Characterized Biospecimens: A Guide for Leveraging Deeply Characterized Biospecimens
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Precision’s tissue biospecimen biorepository

Precision’s tissue biorepository contains >3 million FFPE samples and several million histology slides covering a full spectrum of oncologic and medical diseases

Explore Precision’s tissue biospecimens

Precision’s NGS characterization panels

Precision uses the TruSight™ Oncology 500 (TSO 500) panel and the Oncomine Precision Assay (OPA) panel to characterize oncology biospecimens

 

TSO 500 Selected Biomarkers

LungMelanomaColonOvaryBreastGastricBladderMyeloidPan-cancer

AKT1

BRAF

AKT1

BRAF

AKT1

BRAF

MSH5

ALBL1

MSI

ALK

CTNNB1

BRAF

BRCA1

AR

KIT

PMS2

ASXL1

NTRK

BRAF

GNA11

HRAS

BRCA2

BRCA1

KRAS

TSC1

CALR

DDR2

GNAQ

KRAS

KRAS

BRCA2

MET

CESPA

EGFR

KIT

MET

PDGFRA

ERBB2

MLH1

ETV6

ERBB2

MAP2K1

MLH1

FOXL2

FGFR1

PDGFRA

EZH2

FGFR1

NF1

MSH2

TP53

FGFR2

TP53

FLT3

FGFR3

NRAS

MSH5

PIK3CA

GATA3

KRAS

PDGFRA

NRAS

PTEN

IDH1

MAP2K1

PIK3CA

PIK3CA

IDH2

MET

PTEN

PMS2

JAK2

NRAS

TP53

PTEN

KIT

PIK3CA

SMAD4

MPL

PTEN

TP53

NPM1

RET

RUNX1

TP53

SF3B1

TMB

SRSF2

TP53

OPA Biomarkers

DNA Hotspots
AKT1
ESR1
MAP2K2

AKT2

FGFR1

MET

AKT3

FGFR2

MTOR

ALK

FGFR3

NRAS

AR

FGFR4

NRTK1

ARAF

FTL3

NTRK2

BRAF

GNA11

NTRK3

CDK4

GNAQ

PDGFRA

CDKN2A

GNAS

PIK3CA

CHEK2

HRAS

PTEN

CTNNB1

IDH1

RAF1

EGFR

IDH2

RET

ERBB2

KIT

ROS1

ERBB3

KRAS

SMO

ERBB4

MAP2K1

TP53

CNV
AKT1

AKT2

AKT3

ALK

AR

ARAF

BRAF

CDK4

CDKN2A

CHEK2

CTNNB1

EGFR

ERBB2

ERBB3

ERBB4

Inter-genetic fusions
ALK
NTRK2

BRAF

NTRK3

ESR1

NUTM1

FGFR1

RET

FGFR2

ROS1

FGRF3

RSPO2

MET

RSPO3

NRG1

 -

NTRK1

 -

Intra-genetic fusions
AR

EGFR

MET