Basket, Umbrella and Adaptive Designs for Clinical Trials
Statistical sophistication to design complex clinical programs, with Precision
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Biomarker-driven clinical research can accelerate development timelines, but realizing the full extent of these efficiencies requires advanced trial designs. Precision is built from the ground up to conduct biomarker research, offering robust clinical and translational capabilities.
Accelerate biomarker-driven clinical research with adaptive designs for clinical trials
- Basket Trials
- Umbrella Trials
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Basket Trials: Deep Expertise in Design and Execution
Our team's extensive experience informs our focus on direct application and efficiency, utilizing statistical rigor to manage complex data, streamline processes, and deliver clear results. These designs allows for swift adaptation to emerging data, ensuring that clinical research directly contributes to the development of targeted therapies.
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Umbrella Trials: Specialized, Patient-Centric Strategies
This strategic approach allows us to simultaneously assess various treatments, enhancing the precision of therapeutic matches for patient subgroups. Designs prioritize direct outcomes, data integrity, and operational efficiency, streamlining the route to tangible treatment advancements.
Biomarker data meets rigorous statistical approaches
Case Study
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A basket trial and an accelerated pathway to proof-of-concept
Precision for Medicine had been working with a sponsor on a trial with an adaptive approach to exploring multiple tumor types concurrently as an accelerated pathway to proof-of-concept. However, the study had to overcome multiple challenges including a limited patient population (2% to 8% of all solid tumors), a biomarker approach that was not “standard of care” for all of the targeted cancers, and a complex patient screening process. In addition, the site study staff had to be able to handle highly technical genomic data.
Precision was able to design and implement a clinical trial for this study that has resulted in a total of 20 tumor-specific cohorts pursued and 7 treatment approaches eliminated. The trial continues to add cohorts and tumor-specific explorations, both as single and combination treatment approaches, and what started as 100 patients across 6 sites is now being
conducted at ~50 sites globally with 250+ patients enrolled.
Find out how Precision overcame these study challenges in this case study.
Advance therapeutic breakthroughs with Precision
Explore the breadth of our expertise in therapeutics and modalities as we lead your novel treatments in oncology, rare diseases and beyond, from the groundbreaking idea to clinical realization.
Insights from Precision’s experts
Stay ahead with the latest insights from Precision’s team of experts. Discover valuable perspectives, updates, and strategies in innovative clinical trial design and execution.
Rescuing a Complex Hematology Oncology Trial: Case Study in Precision
Specialized capabilities in every stage of clinical development
Leverage an integrated infrastructure that reduces the inefficiencies inherent in complex development. Integrate lab and trial execution to increase speed to market. Incorporate manufacturing expertise for advances therapies to ensure scalability. Precision can customize and converge our capabilities for your program's unique needs.
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Global CRO
ServicesAward-winning CRO with deep oncology and rare disease expertise
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Global Laboratory
ServicesExceptional translational and biomarker sciences with global central lab services
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Manufacturing
SolutionsPioneers in planning, building and maintaining manufacturing at scale for pharma and biotechs.
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Biospecimens
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Diagnostics & CDx
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Data Intelligence
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Commercialization
Innovative clinical trials, designed with Precision
Explore how designing your clinical program with Precision for Medicine, can maximize timely insights and efficiency.