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Webinar - On Demand

Flow Cytometry for Clinical Applications: Recommendations on Assay Transfer and Method Validation

Spotlight on Immuno-Oncology and Dermatology

Date: July 1, 2022

Duration: 51 Minutes

Flow cytometry analysis can provide incredibly rich data sets, shedding light on biological events at single-cell resolution. However, with many aspects of the validation and monitoring of flow cytometric methods, prospective multicenter immune monitoring trials present several challenges.
 
Among those challenges are the standardization and sample testing reproducibility between different laboratories, particularly on customized flow assays.
 
In this webinar, we will address these challenges and discuss considerations and best practices for intra-laboratory flow cytometry assay transfer and recommendations on method validation for clinical applications.

Topics covered:
  • Advantages of sample testing reproducibility among different laboratories for a more successful transition to clinical settings
     
  • Considerations for choosing the right technologies used in cell-based assay development approaches: example of receptor occupancy (RO) measurement by flow cytometry
     
  • The process toward intra-laboratory assay transfer and overcoming the challenges of standardization/harmonization in flow cytometry
     
  • Points to consider in analytical procedures and method validation for clinical studies

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Speakers

Deb Phippard

Deborah Phippard PhD
Precision for Medicine

Pharma industry veteran and expert at biomarker-driven clinical trial design and execution. Leader of biomarker and drug development programs for pharmaceutical and diagnostics companies, as well as the National Institutes of Health. Spearheaded the discovery of pharmacodynamic biomarkers and novel targets for inflammatory disease therapy.

Laura Lozza

Laura Lozza PhD
Precision for Medicine

Laura has long-standing expertise in immune monitoring and immune assay development with a particular focus on flow cytometry assays. Her focused on human immunology, including characterizing the regulatory activities of CD4 T cells, as well as analyzing the response of human dendritic cells in tuberculosis disease and BCG vaccination.