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Liquid Biopsy Analysis
Gain molecular insights from your liquid biopsy products
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Circulating Tumor Cells
Analyze CTCs to gain information about the underlying status of the cancer:
- Multiple DNA abnormalities
- CTC numbers
- RNA expression and fusion transcripts
- Protein expression
- In vitro/in vivo culture
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Circulating Tumor DNA
Elevated in certain disease process such as cancers, ctDNA genomic sequences can provide insight on cancer type by revealing:
- Amplification and deletions
- Translocations
- Point mutations
- Chromosomal abnormalities
- Number of mutant molecules
Enrich CTCs to maximize your sample insights
Efficiently enrich circulating tumor cells (CTCs) with Precision's proprietary tech, ApoStream®, which leverages differences in the dielectric properties of any cell to isolate target cells and relevant populations, resulting in:
- Higher specificity
- Superior recovery rates and purity
Our range of assay platforms enable the most appropriate approach
Choose the optimal platform to analyze your samples and measure your clinical endpoints. Our multiplatform approach can be especially beneficial in complex development programs, including immuno-oncology, autoimmune, and neurology therapeutic development.
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NGS
Services including RNA-seq, whole exome sequencing, and targeted DNA/RNA sequencing utilizing both Illumina and Thermo-Fisher NGS platforms -
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ddPCR
Advanced ddPCR applications from preclinical to clinical assays including gene therapy viral shedding and CAR T biodistribution
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Single-Cell Sequencing
End-to-end single-cell sequencing solutions utilizing the 10x Genomics Chromium system and Illumina NGS platform
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Multiplex Immuno-fluorescence
Automated multiplex immunofluorescence services that enable quantitative visualization of up to 9 markers in tissue and liquid biopsies -
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FISH/ISH
Development of multiplex FISH/ISH assays to detect abnormalities in a range of tissues, including hematological and solid organ tumors
End-to-end workflows for liquid biopsy enable insights
Collect and Stabilize
Custom kitting with specialized collection tubes paired with shipping logistics expertise and real-time tracking
Prep Your Samples
Standard workflows with robust QC for nucleic acid or cell extraction.
For CTCs, Enrich
Enrich CTCs with dedicated, in-house instruments for greater abundance
Choose the Right Assay for Your Endpoint
Consult with Precision experts to select the appropriate assay for what you're studying
Analyze and Discover
Follow robust, streamlined protocols for each assay type and visualize your data
Precision can collect and perform liquid biopsy analysis on a range of sample types
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Circulating Tumor Cells (CTCs)
Cancer cells from solid tumors migrate into and circulate through the blood and lymphatic system (also known as metastasis)
Difficulty
- Low abundance; present in approximately 1-100 cells per 5 mL of blood
Clinical insight/benefit
- After capture and concentration, analysis provides information about the underlying status of a disease
- Measure DNA abnormalities, CTC count, RNA/protein expression, and in vitro/in vivo cultures
- Much less invasive to perform liquid biopsy than a traditional surgical biopsy
- Low abundance; present in approximately 1-100 cells per 5 mL of blood
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Circulating Tumor DNA (ctDNA)
Small pieces of DNA that are released into a person's blood by tumor cells as the cells die
Difficulty
- Often found in low concentrations, fragmented and with rare mutations
Clinical insight/benefit
- Carries real-time information that can be utilized to identify and track biomarkers of cancers
- Detect and measure mutations like amplifications, deletions, translocations, chromosomal abnormalities, etc.
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Circulating Cell-free RNA (ccfRNA)
Short (20-22 nucleotides), extracellular noncoding RNAs in serum and plasma with potential oncogenic or tumor-suppressive functions
Difficulty
- Requires standardized techniques and robust data evaluation to leverage as a biomarker
Clinical insight/benefit
- Provides information on disease progression and treatment response
Precision also provides research-ready biospecimens
Our liquid biopsy samples come from an extensive network of clinical partner sites in our IRB-approved prospective collection network. Custom collection program and kit design readily available.
Safeguard your samples with custom kitting and expert shipping logistics
Avoid variation in quality and integrity with Precision’s central labs solutions, ensuring the right samples are collected, processed, and transported to exactly where they need to be.
Custom kit production:
- Trial and visit specific kits
- Validated kits for ApoStream
- Multiple sample type kitting
Clinical site training:
- Collection-specific QA plans
- Global shipping and logistics
- Supply chain management
- Online management, tracking and reporting
Leverage sample preparation expertise to increase downstream data quality
Extracting analytes from liquid biopsy samples is difficult due to low analyte abundance, high background levels, and the risk of degradation. Precision's rigorous pre-analytical conditions to assess variability and integrity between samples ensures high-quality molecular tests.
Leverage over 30 years of experience and optimized workflows in sample preparation:
- Standardized and custom SOPs
- Automated instrumentation
- Propriety technologies for enrichment of CTCs
Resources for liquid biopsy and immune monitoring
Explore Precision’s resources to discover best practices and other helpful information.
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