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Webinar - On Demand

Incorporating Tumor Biopsy Spatial Analysis in Oncology Clinical Trials

Date: February 2023

Duration: 50 Minutes

Developing immuno-oncology therapeutics is challenging due to the complexity of cancer and the tumor microenvironment (TME). The TME consists of numerous cellular elements that influence tumor progression and therapeutic response. Over time, the TME can become immunosuppressive, promoting tumor growth and metastasis. Advances in understanding the TME are crucial for improving therapeutic efficacy.
 
Multiplex immunofluorescence (IF) allows for the simultaneous detection of multiple target proteins in tissue samples, providing higher sensitivity and a wider dynamic range than traditional methods. Spatial-omics assists in profiling complex tissues, preserving tissue architecture and revealing biological information without dissociation bias. These technologies help identify and phenotype cell populations, distinguish hot and cold tumors, and guide therapy.
 
Incorporating knowledge of the TME into clinical trials is essential to increase the success rate of oncology drugs. Understanding the phenotypes and spatial arrangement of cells within the TME helps developers better guide therapy and predict outcomes.



Topics covered:

  • Medical and therapeutic importance of tumor spatial architecture
     
  • Digital pathology solutions to assess the tumor microenvironment
     
  • Spatial analysis to assess complex cellular interactions

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Speakers

Gerald Meserschmidt_Photo_Hedcut

Gerald Messerschmidt MD, FACP
Precision Oncology

Oncologist, hematologist and veteran expert in clinical research, clinical practice and development of pharmaceuticals, biologic products and immune modulation therapies. Significant experience and credibility with the FDA and with regulatory authorities in Europe, Japan and other countries.

Amanda Woodroofe

Amanda Woodrooffe PhD
Precision for Medicine

Experienced leader of scientific operations for drug discovery in both the pharmaceutical and CRO industries. Driven to provide actionable data enabling biopharmaceutical research and development. Collaborative partner ensuring licensing and scientific support for corporate development initiatives.

Darren-Davis_Headshot_260x260

Darren Davis PhD
Precision for Medicine

Visionary leader with decades of distinguished biotechnology and clinical translational research experience. Founded ApoCell in 2004 and later was instrumental in developing and commercializing the ApoStream® rare-cell liquid biopsy technology. Globally recognized cancer researcher and the author of more than 100 peer-reviewed publications. Dedicated and committed to improving the lives of patients with debilitating diseases.