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Translational Research - Biomarkers - Rare Diseases
Precision Medicine in Pediatrics: Biomarkers and Assay Development
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Precision offers exceptional scientific depth to support the development of de novo assays, with a particular specialization in cell-based assays and epigenetic immune cell phenotyping using our proprietary and patented Epiontis ID® platform.
Because the purpose of clinical development is to bring new therapies to market, studies often need to find answers for previously unasked questions, questions that don’t fit neatly into one specific method or approach. These are the projects Precision thrives on, devising clever and practical solutions for new challenges.
One example is illustrated in the diagram below where we addressed a client’s need to generate multiple types of biomarker analyses from a single skin punch biopsy. We were able to demonstrate that we could store the biopsy in RNAlater, section the tissue into thirds, and ship to multiple facilities and still obtain accurate and reliable biomarker data.
In the above example, each skin-punch sample was analysed using immunofluorescence and H&E staining, RNA-seq to understand gene expression (NanoString was also an option), and Epiontis ID® for immune cell profiling. Through this custom assay we were able to determine the spatial
distribution and numbers of specific immune cells, and integrate this information with their mRNA signatures, efficiently uncovering complex molecular insights into patient biology that would have been otherwise difficult to obtain.
Our custom assay services support preclinical and clinical research, including multi-site studies, conducted anywhere in the world.
Precision’s specialty lab scientists take a collaborative and consultative approach to projects and can provide recommendations on biomarker assay strategies and implementation. Services can be provided individually or as part of a comprehensive therapeutic development package including biomarker assays and clinical trials.
Customized assays to detect cytokines or proteins of interest utilizing ELISA, Luminex, MSD, SIMOA, and Western Blotting
Read our blog to gain more insights and discover work that Precision has supported.
Translational Research - Biomarkers - Rare Diseases
Translational Research - Biomarkers - Assays
Translational Research - Biomarkers - Assays